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b3,4-Methylenedioxy-N-methcathinone (also known as M1, MDMC, βk-MDMA, and Methylone) is a novel stimulant-entactogen substance of the cathinone class.
Methylone was first synthesized by chemists Peyton Jacob III and Alexander Shulgin in 1996 as a potential antidepressant.
Methylone is sometimes use as a substitute for MDMA due to similarities in their effects. Alexander Shulgin comment that the substances has “almost the same potency of MDMA, but it does not produce the same effects.” He also state that it “has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA.”
The toxicity of methylone has is not well-study, although it likely does not exceed that of MDMA, and it has a limited history of human usage. It is highly advise to use harm reduction practices if using this substance.

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These oxygen group is incorporated into a methylenedioxy ring through a methylene chain. Methylone shares this methylenedioxy ring with MDA, MDAI and MDMA.
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Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. These neurotransmitters to be responsible for regulating pleasure, motivation, focus, and sense of well-being. by inhibiting the reuptake and reabsorption of the neurotransmitters as they have performe their function of transmit a neural impulse, allow it to accumulate be use, which results stimulating and euphoric effect.
In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter (Ki=242.1 nM for methylone to Ki=72 nM for MDMA).

while its affinity for the norepinephrine and dopamine transporters is similar. Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.